Jian Wang Center for Pharma Crystallization, J-Star Research Inc 6 Cedar Drive, Cranbury, New Jersey 08512 Diverse crystallization challenges encountered by CfPC (Center for Pharma Crystallization) and our clients will be analyzed systematically to provide insights into main bottleneck problems in today’s drug development programs. The general approaches taken at CfPC to address such problems as well as opportunities for improvement will be discussed. Examples will be given to highlight how enabling technologies and synergetic partnerships played a critical role in providing timely solutions to great challenges.