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Category : PCS2020

Particle Surface Engineering for Predictive Enhancement of API Properties

Particle surface engineering is a cost-effective, promising route to achieve enhancements in the flowability, bulk density and other properties of a variety of cohesive active pharmaceutical ingredients (APIs). This...

The Crystallisation Structural Pathway of Para Amino Benzoic acid: From Solvated Molecule through Solute Clustering and Nucleation to the Growth of Facetted Crystals

In solution phase crystallisation processes, understanding and controlling the transition pathway associated with the assembly of molecules from their solvated state, into three-dimensional, ordered crystalline-solids, represents a significant grand...

Locality, Strength, and Hierarchy of Intermolecular Interactions in Crystallization

Self-assembling of molecules in crystallization is collectively driven by intermolecular interactions among the solute and solvent. Better understanding of nucleation mechanism may be perceived in light of the locality,...

Partnering for Addressing API Crystallization Engineering Challenges of Today and the Future

In light of the balancing act among quality, speed, and cost, collaborative partnering between pharmaceutical companies and contract research/manufacturing organizations is becoming increasingly important in meeting our goals of...

Integrative Approaches to Addressing Canonical Problems in Pharmaceutical Crystallization

Problems associated with polymorphic instability and increasingly insoluble drug candidates represent white space to innovate novel forms and processing methods with better properties in the drug product. But...

Addressing Bottleneck Problems in Crystallization R&D for New Drug Development

Diverse crystallization challenges encountered by CfPC (Center for Pharma Crystallization) and our clients will be analyzed systematically to provide insights into main bottleneck problems in today’s drug development programs....

Co-processing: An Effective Particle Engineering Approach for Drug Substances

Dr. Deniz Erdemir, Principal Scientist Bristol Myers Squibb, New Brunswick/New Jersey Abstract coming soon

Facilitating DS/DP development through integrated solid-state and crystallization development

Crystallization is an important and economic unit operation for the purification of pharmaceutical API. It also serves as the key step to define the required quality attribute of the...

Pharmaceutical Crystallization Support by Computational Approaches

Given challenges facing the pharmaceutical industry, an accelerated Drug Development greatly benefits from guidance provided by computational methods.<sup>1</sup> This presentation will focus on computational support of the following important...

A Challenging Path to Controlled Nano-API Crystallization and Isolation

Controlled crystallization of an API in submicron size was enabled based on an accurate solubility profile and a growth inhibition property <em>via</em> semi-continuous processing, to meet special formulation requirements....

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