By Drs. Yuriy Abramov
, Center for Pharma Crystallization, J-Star Research
Small molecule drug candidates tend to have different solid forms, including anhydrate, hydrate, solvate, salt, cocrystal and amorphous. Each form displays unique solid-state properties that may profoundly influence bioavailability, stability, manufacturability and other performance characteristics of the drugs. Therefore, it is critical to conduct solid-state research and choose the right crystal form for development based on properties including crystallinity, hygroscopicity, solubility, stability, processability and flowability. This workshop will focus on in-silico & experimental approaches for solid form screen & selection, which includes the rational, methodology and workflow. A case study that illustrates the selection process will be presented.