2022 Q1 Publications
Prof. Calvin (Changquan) Sun of University of Minnesota is a keynote speaker of 2021 Pharma Crystallization Summit (PCS) in the session of Particle Engineering & DS-DP Co-Processing. He presented “Challenges and Opportunities in Optimizing Mechanical Properties of Drugs by Incorporating Excipients”. In 1st quarter of 2022, six new articles have been published by Prof. Sun and his team on pre-formulation, formulation, and material science & engineering.
“Nanomechanical testing in drug delivery: Theory, applications, and emerging trends”, Sushmita Majumder, Changquan Calvin Sun, Nathan A. Mara, Advanced Drug Delivery Reviews 183 (2022) 114167,
The teams of Prof. Sun and Prof. Mara reviewed the applications of nanomechanical testing methods in pharmaceutical industry of recent years. The article clearly highlighted the important role of nanomechanical testing in mechanical properties characterization of drug crystals and developing better knowledge for solid form selection, milling, formulation design and manufacturing.
Publications 2 and 3
“Simultaneous improvement of physical stability, dissolution, bioavailability, and antithrombus efficacy of Aspirin and Ligustrazine through cocrystallization”, Kairu Wang et al, International Journal of Pharmaceutics 616 (2022) 121541
“Complexation with aromatic carboxylic acids expands the solid-state landscape of berberine”, Ziyao Gao, Shuyu Liu, Changquan Calvin Sun, International Journal of Pharmaceutics 617 (2022) 121587
Both papers focus on the solid form studies, new cocrystals were synthesized and showed improved physicochemical properties than the existing forms.
“Air entrapment during tablet compression – Diagnosis, impact on tableting performance, and mitigation strategies”, Gerrit Vreeman , Changquan Calvin Sun, International Journal of Pharmaceutics 615 (2022) 121514
The authors investigated on how air entrapment affects the tablet properties using a compaction simulator and importance of precompression turned out for formulation design.
“Mechanisms of Crystal Plasticization by Lattice Water”, Chenguang Wang, Changquan Calvin Sun, Pharmaceutical Research (2022),
Three mechanisms on the effect of lattice water on crystal plasticization were studied at molecular level. All hydrates are featured with more facile, slip planes, lower packing efficiency, and lower density in 5 different systems than the anhydrates.
“Profound effects of gastric secretion rate variations on the precipitation of erlotinib in duodenum – An in vitro investigation”, Yiwang Guo , Changquan Calvin Sun, International Journal of Pharmaceutics 619 (2022) 121722
The authors investigated the relationship between pH and precipitation behaviors of erlotinib in duodenum, and further impact on bioavailability.
“What Are the Important Factors That Influence API Crystallization in Miscible Amorphous API−Excipient Mixtures during Long-Term Storage in the Glassy State?”, Ann Newman and George Zograf, Mol. Pharmaceutics 2022, 19, 378−391
In this paper, important factors besides min Tg – T value were determined for storage of drug product as amorphous API (or ASDs) and coamorphous systems for long-term, including the ability of the additive to act on thermodynamic and dynamic processes at the local level of bulk and surface phases, particularly to reduce local non-diffusional molecular mobility in addition to bulk diffusional molecular mobility.
“Emerging Landscape of Computational Modeling in Pharmaceutical Development”, Yuriy A. Abramov, Guangxu Sun, and Qun Zeng, J. Chem. Inf. Model. 2022, 62, 5, 1160–1171
In this publication, Dr. Abramov shared an overview on computational chemistry supporting in each step of small molecule drug development process. It states that solid form designs including polymorph, cocrystal, salt and solvate screening got supported from crystal structure prediction (CSP) to guide the crystallization development efficiently, even though there are lots of challenges need to be overcome especially for salt and solvate(hydrate) screening.
Prof. Junbo Gong of Tianjin University is a speaker in 2021 Pharma Crystallization Summit (PCS) in the session of Particle Engineering & DS-DP Co-Processing. He presented “Crystal Habit Modifications and Spherical Crystallization Design in Solution” (see abstract at …). Nine new articles have been published by Prof. Gong and his team in 1st quarter of 2022 on crystal form studies, nanocrystals and experimental-simulation relationship studies.
“Insoluble Salt of Memantine with a Unique Fluorescence Phenomenon”, Wenjie Kuang et al, Mol. Pharmaceutics 2022, 19, 5, 1389–1399
Memantine for Alzheimer’s disease treatment was studied and four crystal forms of insoluble salt Mem−Pam (memantine – pamoic acid) were prepared and characterized. Fluorescence emissions were found different for different crystal forms and might be applied to the slow release of drugs and the real-time monitoring of drug delivery.
“Novel Drug−Drug Multicomponent Crystals of Epalrestat− Metformin: Improved Solubility and Photostability of Epalrestat and Reduced Hygroscopicity of Metformin”, Jingjing Sun et al, Cryst. Growth Des. 2022, 22, 1005−1016
Drug-drug cocrystal of epalrestat (EP) and metformin (MET) (both used for diabetes treatment) showed improved physicochemical properties, in terms of hygroscopicity solubility, dissolution rate, and photostability, compare with individual usage of parent drugs.
“Structural Insights into the Highly Solvating System of Axitinib via Binary and Ternary Solvates”, Haibin Qu et al, Cryst. Growth Des. 2022, 22, 1083−1093
Seven more solvates out of more than 70 were found for Axitinib. The publication states hydrogen bonds, molecular shape, size, and weak interaction forces are important factors to form solvates, and stability of solvates is more related to the interaction energy of the solvent molecules in the crystal structures.
“Bendable and Twistable Crystals of Flufenamic Acid Form III with Bending Mechanofluorochromism Behavior”, Yu Liu et al, Cryst. Growth Des. 2022, 22, 1312−1318
A plastic organic crystal form of flufenamic acid showed unique bending mechanofluorochromism behavior with single face bending. It may provide a new possibility for design of future flexible optical devices and tunable fluorescent materials.
“Theoretical and Structural Understanding of the Different Factors Influencing the Formation of Multicomponent Crystals of 2,4- Dichlorophenoxyacetic Acid with Nheterocyclic Compounds”, -Lan Fang et al, Cryst. Growth Des. 2022, 22, 1707−1719
Multicomponent crystals were prepared by solution crystallization method and studied by computational tools. The main factors of formatting multicomponent crystals include hydrogen bonds, water molecule, conformation and molecular flexibility, etc..
“Ultrasound assisted crystallization of cephalexin monohydrate: Nucleation mechanism and crystal habit control”, Zeren Shang et al, Chinese Journal of Chemical Engineering 41 (2022) 430–440
Ultrasound affects metastable zone width & induction time for cephalexin monohydrate preparation. Parameters, such as ultrasonic power, ultrasonic time, ultrasonic mode, seeding, supersaturation control and removal of fine crystals are important for preparing high-quality monohydrate product.
“Progress and Principle of Drug Nanocrystals for Tumor Targeted Delivery”, Meng Bai et al, AAPS PharmSciTech (2022) 23: 41
The article overviewed drug nanocrystals from four aspects including advantages of nanocrystals, applications of nanocrystals in drugs, targeting mechanisms of nanocrystals in tumors and surface modified of drug nanocrystals.
Papers 8 and 9
“The solid-liquid equilibrium behavior of 2,7-dihydroxynaphthalene in eleven organic solvents: Thermodynamic analysis and molecular simulation understanding”, Lan Fang Li et al, The Journal of Chemical Thermodynamics 170 (2022) 106781
“Thermodynamic analysis and molecular dynamic simulation of the solubility of 2,2-Bis(hydroxymethyl)propionic acid in 12 monosolvents”, Zhixu Li et al, J. Chem. Thermodynamics 164 (2022) 106625
In above two articles, solubility of target molecules in multiple solvents were analyzed both experimentally and computationally. Different models/equations were used for simulation.
“Absolute configuration determination of pharmaceutical crystalline powders by microcrystal electron diffraction (MicroED) via chiral salt formation”, Bo Wang et al, Chem. Commun., 2022, 58, 4711-4714
Dr. Bruhn and team of Biogen demonstrated a new method by Microcrystal electron diffraction (MicroED) to determine configuration of chiral APIs via chiral salt formation. This approach may provide a new tool for determining the absolute configuration of a new API in early drug development. The article was published as front cover paper in ChemComm.
“The interplay of intra- and intermolecular errors in modeling conformational polymorphs”, Gregory J. O. Beran et al, J. Chem. Phys. 156, 104112 (2022)
This study provided how delocalization error impacts the performance of quantum chemistry methods in describing intra- and inter-molecular interactions in conformational polymorphs. The CP1b and CP2b benchmark datasets were generated, which is important for validating quantum chemistry models in challenging real-world systems with complex interplay between intra- and inter-molecular interactions caused by delocalization error.
“A Digital Mechanistic Workflow for Predicting Solvent-Mediated Crystal Morphology: The α and β Forms of L‑Glutamic Acid”, Thomas D. Turner et al, Cryst. Growth Des. 2022, 22, 3042−3059
A digital mechanistic workflow of solvent-mediated morphological prediction model has been developed for routine modeling involved in crystallization process R&D. The study showed the importance of lattice energy and the specific intermolecular interactions on stability of polymorphs.
“Influence of a polymeric additive on the crystallisability and nucleation mechanism for the model fuel system of eicosane crystallising from supersaturated toluene solutions”, Peter L.Kaskiewicz et al, Journal of Crystal Growth 581 (2022) 126470
The impact of improver additive (IA) on crystallisability and nucleation mechanism were studied by two turbidity analysis routes. The effect of IA on solubility, relationship between crystallization temperatures & IA treat rate as well as relationship between IA rate & rate of nucleation were investigated.
Recent Speaker Activities
Four speakers of Pharma Crystallization Summit attended FDA/M-CERSI Co-Processed API Workshop on July 13 and 14, 2022. They are Drs. San Kiang and Jian Wang at J-Star Research (a Porton Company), Prof. Calvin (Changquan) Sun at University of Minnesota, and Dr. Jeremy Miles Merritt at Eli Lilly.
At this event, pharmaceutical researchers, regulatory and materials scientists and manufacturing colleagues from industry, academia, and regulatory agencies gathered to discuss in depth about the needs, benefits and challenges of allowing co-processed API being approved as drug substance vs drug product intermediates.
Dr. Kiang presented at the Workshop on “Strategic Considerations in Choosing a Co-Processing Approach”. Prof. Sun presented on “Excellent CU of Low Dose Direct Compression Tablets Achieved Using Co-Processed API”. Dr. Merritt hosted four of the twelve breakout sessions: a) Justification
During June 19 – 24, 2022, Dr. Yuriy Abramov is going to present at the upcoming Crystal Engineering Gordon Research Conference (https://lnkd.in/g7y9gZnp), on “Computational Support of Pharmaceutical Multicomponent Crystals Design” in the Pharmaceuticals and Cocrystals session.
In his presentation he will focus on two topics of high importance – virtual coformer screening for pharmaceutical cocrystallization, and a novel impurity rejection model. The impurity rejection model considers solvent, lattice-substitution and doping level contributions to impurity incorporation as a solid solution during (re)crystallization. For more information on Dr. Abramov’s work at the Center for Pharma Crystallization (CfPC) of J-STAR Research, Inc., please reach out at firstname.lastname@example.org.
Dr. Shanming Kuang, head of the Center for Pharma Crystallization (CfPC) Shanghai branch of Porton Pharma Solutions Ltd., presented on May 21, 2022, at SAPA Scientific Symposium. In his talk entitled Crystallization Process Development of Small Molecule Drug Candidates Using Solid-State Knowledge, Dr. Kuang illustrated how an in-depth understanding of API solid forms facilitates the proper design of crystallization process, resolves process challenges, and enhances control over drug substance quality attributes.
1. American Crystallographic Association (72nd ACA meeting)
August 3, 2022
Portland Marriott Downtown Waterfront
2. 26th Congress and General Assembly of the International Union of Crystallography
August 22 – 29, 2023
Melbourne Convention & Exhibition Centre, Australia
3. 33rd European Crystallographic Meeting
August 23 – 27, 2022
Music Conservatory and Congress Centre in Versailles, France
4. The 27th International Workshop on Industrial Crystallization (BIWIC 2022)
August 31 – September 2, 2022
September 8-10, 2022
6. 12th American Drug Delivery & Formulation Summit
September 26-27, 2022
San Diego Mission Bay Resort, San Diego, CA
7. 25th International Conference and Exhibition on Pharmaceutical Formulations (Formulation 2022)
September 26-27, 2022
8. Formulation & Drug Delivery Congress
October 11 – 12, 2022
San Diego, USA
9. American Association of Pharmaceutical Scientists (AAPS annual meeting)
October 16-19, 2022
Boston Convention & Exhibition Center, Boston, MA
10. 2022 AIChE Annual Meeting
November 13-18, 2022
Phoenix Convention Center, Phoenix, AZ
11.International Conference on Industrial Crystallization Processes
December 02-03, 2022
12.LNP Formulation & Process Development Summit
13.Gordon Research Conference
a) Crystal Growth and Assembly (Gordon Research)
June 17 – 18, 2023
Mechanistic Understanding of the Growth and Assembly of Ordered Materials
June 18 – 23, 2023
b) Liquid Crystals (Gordon Research Conference)
June 24 – 25, 2023
June 25 – 30, 2023
14. International Symposium on Crystallization