By Dr. Samir Kulkarni, Ph.D. Pfizer, Groton, CT The improved development and scaleup of Nirmatrelvir (the active 3CL protease inhibitor in PaxlovidTM) with efficient chemical synthesis led to FDA...
By Dr. Ashish Punia, Ph.D. Merck & Co., Rahway, NJ A considerable portion of small molecule pharmaceutical drugs suffer from poor aqueous solubility. Amorphous solid dispersion (ASD) is a...
By Prof. Rajesh N. Davé, Distinguished Professor, Chemical & Materials Engineering, New Jersey Institute of Technology, Newark, NJ 07102 Distinguished Professor of Chemical, Biological and Pharmaceutical Engineering, Center for...
By Prof. Changquan Calvin Sun, Ph.D. Professor, University of Minnesota The development of a quality tablet product requires overcoming deficiencies in pharmaceutical properties of tablets to meet several performance...
By Prof. Ronald Siegel, Professor and Department Head, Department of Pharmaceutics, University of Minnesota, Minneapolis, MN 55455 For many low solubility drugs, the crystalline form is unfavorable due to...
By Samuel kyeremateng, Ph.D. AbbVie, North Chicago, IL Small molecule solid dosage drug product with the drug in the crystalline state is typically preferred due its more desirable properties...
By Dr. Bo Wang, Ph.D. Biogen, Cambridge, MA Absolute configuration determination of an active pharmaceutic ingredient (API) is a crucial task in drug development. Tremendous scientific and technical progress...
By Dedong Wu, Ph.D. Advanced Drug Delivery, PharmSci, R&D, AstraZeneca, Boston US dedong.wu@astrazeneca.com It is challenging and laborious to identify a crystallization process to access an optimal drug substance...
By Scott Shultz, Ph.D. Department of Analytical Research and Development, Merck & Co., Inc., Rahway, NJ, USA The role of the crystalline solid phase is often an enabling feature...
By Cheng Yi Chen, Ph.D. Chemical Processing R&D, Mirati Therapeutics, San Diego, CA 92130, USA chenc@mirati.com A new approach to stereopure atropisomeric molecules is enabled by a continuous flow-crystallization...
