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Development of a scalable atroposelective process to MRTX1719-an inhibitor of the PRMT5*MTA complex

By Cheng Yi Chen, Ph.D. Chemical Processing R&D, Mirati Therapeutics, San Diego, CA 92130, USA chenc@mirati.com A new approach to stereopure atropisomeric molecules is enabled by a continuous flow-crystallization...

Drug Substance Physical Property Control in the Process of Crystallization

By Haitao Zhang, Ph.D. Associate Research Fellow, Sumitomo Pharma America, Inc. The crystallization of active pharmaceutical ingredients, particularly those with multiple polymorphic forms, particle size and morphology critical properties,...

Enabling efficient synthetic route selection by robust purification in crystallization

By Fredrik Nordstrom, Ph.D. Material and Analytical Sciences, Boehringer-Ingelheim, Ridgefield, CT, 06877 fredrik.nordstrom@boehringer-ingelheim.com The decision for selecting and optimizing the synthetic route of a drug candidate is to a...

Dr. Fredrik Nordstrom

Dr. Fredrik Nordstrom leads a solid state and crystallization group within the Material and Analytical Science department at Boehringer-Ingelheim, Ridgefield, CT. The Solid State Chemistry group is responsible for...

Dr. Luca Iuzzolino, Merck & Co.

Luca Iuzzolino works as a Senior Scientist in the Computational and Structural Chemistry (CSC) group within Merck & Co., Inc. His work place is in Rahway, NJ. In his...

Dr. Vivian Bi, Aclaris Therapeutics

Dr. Vivian Bi is a Senior Director and Head of Pharmaceutical Development at Aclaris Therapeutics Inc., where she looks after the development of multiple pharmaceutical products from preclinical to...

Dr. Veeran Gowda Kadajji, J-STAR Research

Veeran Gowda Kadajji, holds a PhD in Pharmaceutical sciences. In his current role, he leads drug product development group at J-STAR Research in Cranbury, NJ. He has close to...

Dr. Qi Gao, J-Star Research

Dr. Qi Gao is a Distinguished Research Fellow of J-Star Research. She received a B.S. degree in Chemical Engineering and Materials Science from Tsinghua University and a Ph.D. in...

Dr. Kaushalendra Chaturvedi (KC), J-Star Research

Dr. Kaushalendra Chaturvedi is a Sr. Research Scientist at J-Star Research Inc., in the Center for Pharma Crystallization (CfPC) and Drug Product Development group (DPD). His research is focused...

Dr. John A. Grosso, Arvinas

Dr. Grosso is the Senior Vice President of R&D Technical Operations at Arvinas Inc. He is responsible for active ingredient and drug product development, scale-up, manufacturing, and clinical supply...

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