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Intelligent Cloud-Based Algorithms for Reducing Risk in Crystallization Process Development

By Dr. Mike Bellucci, XtalPi Inc   Crystallization is the most widely used separation and purification process in the pharmaceutical industry.  The resulting crystal structure and corresponding crystal morphology...

A Digital Mechanistic Workflow for Predicting Solvent-Mediated Crystal Morphology

By Prof. Kevin Roberts, University Of Leeds   The crystallization of organic materials provides a common, energy efficient methodology for the purification and isolation of high value compounds such...

Prof. Kevin Roberts, University of Leeds

Kevin Roberts is currently Brotherton Professor of Chemical Engineering at the University of Leeds in the UK where he is also Director of the EPSRC’s Centre for Doctoral Training...

Simulation aided solvent selection for robust impurity rejection by crystallization

By Dr. Yuriy Abramov, Exe. Director of CC&DS, J-Star Research Regulatory expectations for control of impurities in new drugs have been established through ICH guidelines. The most efficient approach...

A new approach to stere-opure atropisomeric molecules enabled by continuous flow-crystallization

By Dr. Michal Achmatowicz, Mirati Therapeutics Abstract: A new approach to stereopure atropisomeric molecules is enabled by a continuous flow-crystallization process. Continuous accumulation of the product under its optimal...

Dr. Michal Achmatowicz, Mirati Therapeutics

Dr. Michal Achmatowicz received Ph.D. in organic chemistry in 2001 after working with Prof. Janusz Jurczak at the University of Warsaw and the Institute of Organic Chemistry of the...

Combined In-Silico & Experimental Approach for Solid Form Screen & Selection

By Drs. Yuriy Abramov and Shanming Kuang, Center for Pharma Crystallization, J-Star Research Small molecule drug candidates tend to have different solid forms, including anhydrate, hydrate, solvate, salt, cocrystal...

Dr. Shanming Kuang, J-Stat Research/ Porton

Dr. Shanming Kuang is currently the Head of Center for Pharma Crystallization at Porton Shanghai and Senior Director of Solid Form Studies at J-Stat Research. Shanming obtained his PhD...

Dr. Yuriy Abramov, J-Star Research

Dr. Yuriy Abramov is an industrial computational scientist with over 18 years experience at Pfizer Inc. Currently he holds a position of an Executive Director of computational chemistry and...

Dr. Nima Yazdanpanah, Procegence

Dr. Nima Yazdanpanah is a consultant on advanced manufacturing and modeling and simulation applications in Bio/pharmaceutical and fine chemical industries. His area of expertise covers process simulation, particulate matters,...

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