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Richard Becker, BlazeMetrics

Richard is the Managing Director of Blaze Metrics, a company that designs, develops, and assists their customers to implement and apply cutting edge In-Process Microscopy, Spectroscopy, & Analytics from...

Amorphous or Crystalline? Using Next Generation PAT to Track API Particle Attributes for Enhanced Downstream Processability

By Richard Becker, BlazeMetrics   Process Analytical Technology (PAT) has dramatically expanded its capabilities over the last decade. Today’s PAT enables an in-depth understanding of process behavior on both...

Particle engineering by spray drying: process dev., scale-up, and technology transfer

By Dr. Nima Yazdanpanah, Procegence Drug substance isolation by crystallization and filtration and spray drying are last stages of the drug substance manufacturing process, where critical quality attributes (CQAs)...

Dr. Mike Bellucci, XtalPi Inc

Dr. Michael Bellucci is a Senior Director at XtalPi, Inc. where he leads a research team that develops algorithm technologies for solid form development and risk assessment as well...

Intelligent Cloud-Based Algorithms for Reducing Risk in Crystallization Process Development

By Dr. Mike Bellucci, XtalPi Inc   Crystallization is the most widely used separation and purification process in the pharmaceutical industry.  The resulting crystal structure and corresponding crystal morphology...

A Digital Mechanistic Workflow for Predicting Solvent-Mediated Crystal Morphology

By Prof. Kevin Roberts, University Of Leeds   The crystallization of organic materials provides a common, energy efficient methodology for the purification and isolation of high value compounds such...

Prof. Kevin Roberts, University of Leeds

Kevin Roberts is currently Brotherton Professor of Chemical Engineering at the University of Leeds in the UK where he is also Director of the EPSRC’s Centre for Doctoral Training...

Simulation aided solvent selection for robust impurity rejection by crystallization

By Dr. Yuriy Abramov, Exe. Director of CC&DS, J-Star Research Regulatory expectations for control of impurities in new drugs have been established through ICH guidelines. The most efficient approach...

A new approach to stere-opure atropisomeric molecules enabled by continuous flow-crystallization

By Dr. Michal Achmatowicz, Mirati Therapeutics Abstract: A new approach to stereopure atropisomeric molecules is enabled by a continuous flow-crystallization process. Continuous accumulation of the product under its optimal...

Dr. Michal Achmatowicz, Mirati Therapeutics

Dr. Michal Achmatowicz received Ph.D. in organic chemistry in 2001 after working with Prof. Janusz Jurczak at the University of Warsaw and the Institute of Organic Chemistry of the...

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